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Symbol
Name
ID

Notch3
notch 3
MGI:99460

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Ventricular septal defect	Bicuspid aortic valve	Aortic aneurysm	Patent ductus arteriosus	Varicose veins	Stroke	Lacunar stroke	Vascular granular osmiophilic material deposition
Disease(s) Associated with NOTCH3	Ventricular septal defect	Bicuspid aortic valve	Aortic aneurysm	Patent ductus arteriosus	Varicose veins	Stroke	Lacunar stroke	Vascular granular osmiophilic material deposition
CADASIL 1
lateral meningocele syndrome

Mouse Phenotypes

cardiovascular system phenotype

abnormal artery morphology

poor arterial differentiation

abnormal retina blood vessel morphology

abnormal pericyte morphology

abnormal vascular smooth muscle morphology

abnormal heart morphology

increased heart weight

enlarged heart

abnormal blood circulation

abnormal vascular resistance

Availability

Mouse Genotype

Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg}

*

Notch3^{tm1.1(KOMP)Vlcg}/Notch3^{tm1.1(KOMP)Vlcg}

Notch3^tm1.1Dwr/Notch3^tm1.1Dwr

*

Notch3^tm1Grid/Notch3^tm1Grid

Notch3^tm1Ul/Notch3^tm1Ul

*

Notch3^tm1.1Dwr/Notch3⁺

*

Notch3^tm1Ul/Notch3⁺

*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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